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・ Nipponotrophon scitulus
・ Nipponotrophon shingoi
・ Nipponotrophon stuarti
・ Nipponzan-Myōhōji-Daisanga
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・ Nippoptilia cinctipedalis
・ Nippoptilia distigmata
・ Nippoptilia issikii
・ Nippoptilia philippensis
・ Nippoptilia pullum
・ Nippoptilia rutteni
・ Nippoptilia spinosa
・ Nippoptilia vitis
・ Nippori Station
・ Nippori-Toneri Liner
Nippostrongylus brasiliensis
・ Nippu
・ Nippu Jiji
・ Nippu Ravva
・ Nippulanti Manishi
・ Nippur
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・ Nipputo Chelagaatam
・ NIPPV
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Nippostrongylus brasiliensis : ウィキペディア英語版
Nippostrongylus brasiliensis

''Nippostrongylus brasiliensis'' is a gastrointestinal roundworm or nematode that infects rodents, primarily rats. This worm is a widely studied parasite due to its simple life-cycle and its ability to be used in animal models. It has a life-cycle similar to the human hookworms ''Necator americanus'' and ''Ancylostoma duodenale'' which includes five molting stages to become sexually mature.
== Life cycle ==
The life cycle is similar to that of the human hookworms, ''Necator americanus'' and ''Ancylostoma duodenale''.
Eggs located within the soil release motile, free-living worms that must molt twice (L1 and L2) in order to develop into their infective L3 stage. This L3 stage can penetrate through intact skin in as little as 4 hours. Once inside the host, the worms invade the venous circulation and are carried into the lungs, where they become trapped in the capillaries. When the worms mature into the L4 stage they rupture the capillaries and are released into the alveoli where they are coughed up and swallowed. They then reach the small intestines 3–4 days after the initial infection. The worms become adults after the final molt into the L5 stage where they begin laying eggs on the 6th day of infection.〔Locksley, Richard M., and Miranda Robertson. "11.4." Immunity: The Immune Response in Infectious and Inflammatory Disease. By Anthony L. DeFranco. N.p.: New Science, 2007. 274-75. Print.〕 The eggs are passed out of the host through feces and the cycle starts all over again.
''N. brasiliensis'' are adapted to infecting rats and so can continue laying eggs for prolonged periods of time. The immune response of mice however, leads to cessation of egg laying by day 8 and adults are expelled by day 10.〔Locksley, Richard M., and Miranda Robertson. "11.4." Immunity: The Immune Response in Infectious and Inflammatory Disease. By Anthony L. DeFranco. N.p.: New Science, 2007. 274-75. Print.〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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